SPONTANEOUS TUMORS IN SPRAGUE-DAWLEY (CO: Crj) RATS
スポンサーリンク
概要
- 論文の詳細を見る
The spontaneous tumors in Sprague-Dawley rats were studied in 510 females and 450 males which have been used as control groups of various chronic toxicity tests. The incidence of spontaneous tumor was 86.9% in males and 96.0% in females, respectively. In female rats, the most frequent tumor was pituitary adenoma, and followed by breast tumor, insuloma, and adreno-cortical adenoma. In contrast, pituitary adenoma, insuloma, adrenal pheochromocytoma, and hepatic tumor were common tumors in males. The incidence of pituitary adenoma, mammary tumor, thymoma, and adrenocortical adenoma was higher in females than males. On the other hand, the incidence of lung tumor, hepatocellular carcinoma, follicular cell adenoma of the thyroid, pheochromocytoma, and renal tumor was higher in males. Leukemia was also noted about 2.3% in males and 0.8% in females, and all of them were myelogenic leukemia. Moreover, various other tumors were found in other organs or tissues, but their incidences were low.
- 日本毒性病理学会の論文
日本毒性病理学会 | 論文
- Hepatocellular Carcinoma with PIVKA-II Production in a Young Laboratory Monkey
- Latent Infection of Canine Herpes Virus in Laboratory Beagle Dogs
- Age-specific and Dose-dependent Retinal Dysplasia and Degeneration Induced by a Single Intraperitoneal Administration of N-Methyl-N-nitrosourea to Rats
- Inhibitory Effects of Octreotide Acetate, a Somatostatin Analog, on Spontaneous Chronic Pancreatitis in WBN/Kob Rats
- Rapid Screening for Chemopreventive Agents in Herbal Extracts in a PhIP Rat Model with DNA Adduct and Cell Proliferation as End-Points