GROWTH BEHAVIOR OF TRANSPLANTABLE OSTEOSARCOMAS OCCURRING SPONTANEOUSLY AND INDUCED BY 4-HYDROXYAMINOQUINOLINE 1-OXIDE IN FISCHER 344 RATS
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The growth behavior of two transplantable osteosarcomas, spontaneously occurring and a carcinogen, 4-hydroxyamino-quinoline 1-oxide (4-HAQO), induced in Fischer 344 rats are described. The transplantability of those neoplasms was more than 80% and their doubling time ranged from 2.8 to 5 days. At the present time, the tumor occurring spontaneously is in the 17th generation and the 4-HAQO induced one is in the 14th generation. In spontaneously occurring osteosarcoma, numerous osteoid formation was observed but by serial transplantation osteoid formation decreased and disappeared by the 10th generation. On the other hand, in 4-HAQO induced osteosarcoma, osteoid formation was maintained by serial transfer and pulmonary metastasis occurred in animals receiving subcutaneous transplantation. These results provide a useful experimental model for studying tumor cell differentiation in forming osteoid and pulmonary metastasis.
- 日本毒性病理学会の論文
日本毒性病理学会 | 論文
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