PROMOTING EFFECTS OF URACIL-INDUCED UROLITHIASIS ON URINARY BLADDER CARCINOGENESIS OF RATS PRETREATED WITH VARYING DOSES OF N-BUTYL-N-(4-HYDROXYBUTYL) NITROSAMINE AND LACK OF INITIATING ACTIVITY OF URACIL
スポンサーリンク
概要
- 論文の詳細を見る
Promotion potential of uracil-induced urolithiasis on rat bladder carcinogenesis of male F344 rats pretreated with 0.05, 0.01, 0.005 or 0.001% of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) was investigated. Enhancement of induction of papillomas and carcinomas by 3% uracil was observed only in rats given 0.05% BBN. Initiation activity of uracil on urinary bladder carcinogenesis was also studied using promotion by NaHCO3. No tumor was seen in a uracil-NaHCO3 group whereas increased incidences of tumors were observed in a BBN-NaHCO3 group.
- 日本毒性病理学会の論文
日本毒性病理学会 | 論文
- Hepatocellular Carcinoma with PIVKA-II Production in a Young Laboratory Monkey
- Latent Infection of Canine Herpes Virus in Laboratory Beagle Dogs
- Age-specific and Dose-dependent Retinal Dysplasia and Degeneration Induced by a Single Intraperitoneal Administration of N-Methyl-N-nitrosourea to Rats
- Inhibitory Effects of Octreotide Acetate, a Somatostatin Analog, on Spontaneous Chronic Pancreatitis in WBN/Kob Rats
- Rapid Screening for Chemopreventive Agents in Herbal Extracts in a PhIP Rat Model with DNA Adduct and Cell Proliferation as End-Points