NUCLEAR DNA CONTENT OF ACINAR CELL HYPERPLASTIC AND NEOPLASTIC LESIONS IN RAT AND HUMAN PANCREAS
スポンサーリンク
概要
- 論文の詳細を見る
Pancreatic acinar cell hyperplastic lesions and neoplasms were examined for nuclear DNA content by microspectrophotometry. Hyperplastic acinar cell lesions induced in rats by azaserine displayed a wide range of DNA contents, 1.5C-7C for acidophilic cell type and 1.5C-7.5C for basophilic cell type compared with the euploid pattern of 1.5C-5C in normal pancreas. On the other hand, the modal DNA values of rat acinar cell adenomas were distributed over a wider range of 2C-8.5C. In acinar cell carcinoma, the DNA histogram showed an aneuploid pattern of 2C-9C. In human pancreas of autopsy cases, hyperplastic acinar cell lesions composed of eosinophilic cells displayed a slightly wider range of DNA content (1.5C-6.5C) than that in normal acinar cells (1.5C-5C) or that in surrounding acinar cells without pathological change (1.5C-6C). The DNA histogram of basophilic cell type hyperplastic lesions were of an aneuploid pattern (2.5C-8.5C) similar to that of an acinar cell carcinoma (2C-10.5C). Acinar cell adenoma showed a polyploid pattern in its histogram (1.5C-8.5C). These findings suggest that acinar cell hyperplastic lesions in rat and human probably are precursors for acinar cell neoplasms.
- 日本毒性病理学会の論文
日本毒性病理学会 | 論文
- Hepatocellular Carcinoma with PIVKA-II Production in a Young Laboratory Monkey
- Latent Infection of Canine Herpes Virus in Laboratory Beagle Dogs
- Age-specific and Dose-dependent Retinal Dysplasia and Degeneration Induced by a Single Intraperitoneal Administration of N-Methyl-N-nitrosourea to Rats
- Inhibitory Effects of Octreotide Acetate, a Somatostatin Analog, on Spontaneous Chronic Pancreatitis in WBN/Kob Rats
- Rapid Screening for Chemopreventive Agents in Herbal Extracts in a PhIP Rat Model with DNA Adduct and Cell Proliferation as End-Points