SPONTANEOUS MAST CELL TUMOR IN NINE CASES OF MICE
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概要
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Nine mast cell tumors were found in 4, 000 mice used in chronic toxicological tests or carcinogenicity tests. Seven cases were diagnosed as malignant mastocytosis and the other two cases were diagnosed as mastocytoma. These neoplastic mast cells had a slightly larger cytoplasm and clear nuclei as compared with the normal mast cells, but their cytoplasmic granules showing a marked metachromasia by toluidine-blue stain were very fine similar to those of normal mast cells. Consequently, these cells were considered to be well-differentiated. The incidence of mast cell tumor was higher in the male than in female mice. Other features of mast cell tumors in mice were: a paucity of infiltration of eosinophils, proliferation of collagen fibers, edema, and other stromal reaction, were considered to be characteristic as compared with the mast cell tumors in other animals.
- 日本毒性病理学会の論文
日本毒性病理学会 | 論文
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