ゼブラフィッシュに及ぼすフェノ-ルの慢性毒性〔英文〕

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Duplicated groups of 9 zebrafish, 3 females and 6 males, were exposed to 2.2, 4.9 and 24 ppm phenol solutions for 3 months. The fish behaved abnormally at 4.9 and 24 ppm almost im-mediately after placement in the test aquaria. The effect of phenol toxicity on the gill, ovary, kidney, intestine, and blood cells were studied carefully. The extent of damage of these organs and also the abnormal behavior were more severe at 24 ppm than at 4.9 ppm. Histological pictures of the studied organs and behavior of the fish at 2.2 ppm were almost similar to those at controls. Most of the fish at 24 ppm died within a few days, but some remained alive till the end of the experiment. However, no fish died at 4.9 and 2.2 ppm. The survived fish gradually recovered from the initial damage and showed improved condition till the end of the experiment. None of the fish spawned at 24 ppm, though all the fish at 2.2 and 4.9 ppm spawned frequently, The interval between spawnings were longer at 2.2 and 4.9 ppm than at control groups. The off-spring (eggs and larvae) of 4.9 ppm which were cultured in the same concentration all died within 7-12 days. Whereas some of those transferred to the control water survived and were cultured for 2 months and grew successfully. The off springs of 22 ppm which were cultured in the same concentration and control water survived and grew at a rate almost equal to those of the control group.
日本水産學會の論文