Insulinおよび2-Deoxy-D-glucoseによる迷走神経性胃分泌刺激剤に対するγ-OryzanolとAtropineの作用比較

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The inhibitory effects of γ-oryzanol and atropine on the gastric secretion were studied using insulin and 2-deoxy-D-glucose as vagal stimulants. Pretreatment with γ-oryzanol (100 mg/kg, s.c., once daily×5) dep-ressed the gastric secretion stimulated by insulin or 2-deoxy-D-glucose, but the potency was less than that with atropine (10 mg/kg, s.c.). γ-Oryzanol had no effect on decrease in the serum glucose level or on increase in the gastrin level induced by insulin injection, while atropine enhanced these responses. From these results, it is considered that the inhibitory action of γ-oryzanol on gastric secretion may be due to depression of the vagas system but the mode of action is different from that of atropine.
社団法人日本薬理学会の論文