The toxicity of the mesoxalates and histological observations after continuous administration

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概要

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• This is a report concerning studies of the toxicity of the mesoxalates in normal rabbits and rats, together with the histological examination of several main internal organs over an extended period of continuous administration. The minimum lethal dose was undetermined on account of its less toxicity, and there were no perceptible side effects in long administration of the drug. The marked proliferation or neogenesis of β cell in the islets of <I>Langerhans</I> were found in rabbits which were administered the drug for 3 or 4 months, and in rats administered over 6 months. No substantial histological changes were noted in the liver, kidney and spleen in rats even after 12 months of the continuous administration.

• 社団法人 日本薬理学会の論文

著者

• 小林 芳人

  東京大學醫學部藥理學教室

• 池田 良雄

  國立衛生試験所

• 菊地 健三

  國立衛生試験所

• 大橋 茂

  東京大學醫學部藥理學教室

• 竹内 節彌

  東京大學醫學部藥理學教室

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• Mechanism of anti-diabetic activity of the mesoxalates
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• The effect of calcium mesoxalate on the insulin content of the pancreas

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