メゾ蓚酸塩の抗糖尿病作用に関する研究第1報 Alloxan-糖尿病家兎に対するメゾ蓚酸塩の影響

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Our experiments corroborated that when sodium or calcium salt of mesooxalic acid was given orally to alloxan-diabetic rabbit for several days, daily amount of sugar in the urine decreased or disappeared totally, the non-protein nitrogen in the urine decreased markedly and the level of sugar and acetone bodies in the blood fell, resulting the increase of the body weight of rabbit affected. If the administration of the drug was sustained, glycosuria reappeared from the selfsame day and the body weight, blood sugar content and other findings returned to their respective level prior to the drug was given. The more serious the diabetes in rabbit, the less the effect of the drug. From the histological studies on the pancreas of rabbit tested it was proved that the intensive and typical change of the islet of <I>Langerhans</I> induced by alloxan was found in all of our experiments to which the drug was not or less effective.
社団法人日本薬理学会の論文