Effect of salts of meso-oxalic acid against alloxan diabetes in dog

概要

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The salts of meso-oxalic acid showed the remarkable effect against the alloxan diabetes in dog as it had been proved in rabbit. In the diabetic dog the abnormal value observed in the blood and urine was restored to the normal level during the oral administration of drug and often for a few days after giving up the administration in less the dose than in rabbit. The anticipated effect was proved by giving and adequate amount of insulin prior to the administration of meso-oxalic acid to dog when the drug alone was not effective for the very severe diabetic animal. It was also revealed that there was no effect for the depancreatized dog in any doses of the drug.
社団法人日本薬理学会の論文