Alkylresorcinolsの配合に関する研究-3-

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概要

• 論文の詳細を見る

• On the combination of 4-<I>n</I>-octyl-6-chlororesorcinol (O.C.R.) and 4-<I>n</I>-octylresorcinol (O.R.), marked potentiation was observed as to the ascaricidal power <I>in vitro</I> (1 : 1000) as well as to the clinical anthelmintic efficacy. The most efficient ratio of the mixture was 70 parts of O.C.R. to 30 parts of O.R. (equivalent to O.C.R. <I>ca</I>. 2mol : O.R. <I>ca</I>. 1 mol.), and its efficacy was obviously more excellent than hexylresorcinol. As to the oral toxicity to mice and the irritant action to the mucous membrane (on the conjunctiva of rabbits and human tongues), this mixture lay between O.R.and O.C.R., and was far weaker than hexylresorcinol. A 0.2 g per kg dose was almost harmless to the dog's gastric mucosa. Possible relationship between the potentiation of the ascaricidal property and some physical changes observed such as a lowering of interfacial tension of solution and a fall of melting point of the mixtures was discussed.

• 社団法人 日本薬理学会の論文

著者

• 万波 忠三郎

  岡山大學醫學部藥理學教室

• 高岡 健男

  岡山大學醫學部藥理學教室

• 山崎 英正

  岡山大學醫學部藥理學教室

関連論文

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• Alkylresorcinolsの配合に関する研究-3-
• Effects of the surface active agents upon the toad's nematoda killing efficacy of cyclohexylchlororesorcinol
• Sdudies on the combined actions of alkylresorcinols as an anthelmintic.:I. Combination of 4-cyclohexyl-6-chlororesorcinol and 4-n-octyl-6-chlororesorcinol. II. Combination of 4-cyclohexyl-6-chlororesorcinol and 4-n-octylresorcinol
• Quinone monoxin methyletherの薬理学的研究(1)-一般作用,毒性,運動神経,骨格筋,及び血液に及ぼす影響-

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