Effects of the surface active agents upon the toad's nematoda killing efficacy of cyclohexylchlororesorcinol

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概要

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• Several kinds of surface active agents-i.e., cationic : cetylmethyl diethyl ammonium methosulfate, cetylmethyl piperidinium methosulfate, non-ionic : Tween 20, Tween 60, and Span 20, anionic : dioctyl ester sodium sulfosuccinic acid, sodium oleate-were added according to the various steps of concentration to 0.01% solution of 4-n-cyclo-hexyl-6-chlororesorcinol (C. H. C. R.) in phosphate buffered, pH 7.5, frog-<I>Ringers</I>' solution. Then, the mortality percent of Spinicauda japonica <I>Wilkie</I>, a nematoda species inhabiting toad's large intestine, after immersed in these solutions for certain minutes, was observed by modified <I>Lamson</I>'s method, and parallel measurement was carried out their interfacial tension against liquid-parrafin by <I>Hillyer</I>'s drop method and <I>du Nouy</I>'s ring method. The results obtained were : the soaps in dilute solution increased remarkably the biological activity of C. H. C. R. (as measured by the mortality percent) but when present in high 'concentration it decreased the activity. In these cases, the least concentration of soap to increase the biological activity of these solutions corresponded to the concentration at which the interfacial tenision bgins to fall, when measured by drop method, but not by ring method, but the maximum acceleration ot the activity occurred at the concentration where the interfacial tension by ring method indicated minimum. However, in the case of Tween, such acceleration of the biological activity of the solution was not observed throughout its concentrations, and the more concentrated the more markedly decreased. These results were discussed from the sufacechemical point of view.

• 社団法人 日本薬理学会の論文

著者

• 万波 忠三郎

  岡山大學醫學部藥理學教室

関連論文

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• Effects of the surface active agents upon the toad's nematoda killing efficacy of cyclohexylchlororesorcinol
• Sdudies on the combined actions of alkylresorcinols as an anthelmintic.:I. Combination of 4-cyclohexyl-6-chlororesorcinol and 4-n-octyl-6-chlororesorcinol. II. Combination of 4-cyclohexyl-6-chlororesorcinol and 4-n-octylresorcinol
• Quinone monoxin methyletherの薬理学的研究(1)-一般作用,毒性,運動神経,骨格筋,及び血液に及ぼす影響-

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