Sdudies on the combined actions of alkylresorcinols as an anthelmintic.:I. Combination of 4-cyclohexyl-6-chlororesorcinol and 4-n-octyl-6-chlororesorcinol. II. Combination of 4-cyclohexyl-6-chlororesorcinol and 4-n-octylresorcinol

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On the combinations between 4-cyclohexyl-6-chlororesorcinol. (C. H. C. R.) and 4-<I>n</I>-octyl-6-chlororesorcinol (O. C. R.), C. H. C. R. and 4-<I>n</I>-octylresorcinol (O. R.), remarkable potentiation of the efficiency in combating ascaris was observed in certain ratio of mixture. The most efficient ratio of mixture, in both cases lay within the rang e of from 90% of C. H. C. R. contained. Oral toxicity tomice, local irritant action (examined on conjunctiva of rabbits, human tongues and gastric mucosa of dogs and also clinical side effects of these mixtures of most efficatious ratios did not significantly differ from those of C. H. C. R., the fact revealing no potentiation in such aspects. These mixtures proved, to be superior in anthelmintic efficacy and less toxic and less irritant than hexylresorcinol. Some physical changes such as a fall of melting, point and a lowering of interfacial tension of solution are supposed to be important factors in the mechanism of anthelmintic potentiation of these mixtures.
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