赤血球膜の機械的脆弱性--血栓形成における役割への考察

概要

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Membrane fragility and deformability of erythrocytes were reviewd briefly, and a new, simple and quantitative method for studying mechanical fragility of red cell membrane was discussed. An advantage of this fragility test is that it can be carried out under physiological conditions such as isotonic medium and normal hematocrit value. Mechanical fragility of erythrocytes give us unique information concerning membrane stability related to molecular constituents of membrane, which are not detected by other method such as osmstic test and spin labeling. Furthermore, a new method for platelet aggregation in whole blood was introduced. A possible influence of mechanical fragility of erythrocytes upon platelet aggregation was discussed. Mechanical fragility as well as deformability of erythrocytes might be of clinical importance in maintenance of microcirculation and pathogenesis of thromboembolism.
日本膜学会の論文