肺結核患者血中の結核菌蛋白に対する沈降抗体と補体結合抗体

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The authors titrated precipitins and complement fixing activities to tuberculoproteins in sera from patients with pulmonary tuberculosis. Cells of human tubercle bacilli (Frankfurt stra in)were mechanically disintegrated by the equipment designed by one of the authors. A crude protein fraction extracted from them with minimum denaturation was used as the antigen. Precipitin titration was carried out by the agglutination reaction of antigen-coated collodion particles elaborated by the authors.<BR>Complement fixation performed against the native tuberculoproteins was of high diseasespecificity. No healthy positive reactor to tuberculin had 1/20 or higher titers, while vast majority of 335 tuberculous patients revealed higher titers than 1/20 reaching 1/640 in serious cases. The serological reaction, therefore, was useful in making differential diagnosis of abnormal chest shadows, in speculating prognosis and confirming recovery of pulmonary tuberculosis.<BR>Precipitins to tuberculoproteins were comparatively scant (1/5-1/20) in hopeless patients suffering from severe disease and in recovered patients as well as in healthy positive reactors. Precipitins were plentiful (1/40-4/160) only in improving patients whose chest shadows were diminishing steady.<BR>It was o f interest to notice that excessive production of the precipitins to the mostly noxious bacillary element (tuberculoproteins) accompanied a favourable clinical condition, whereas low blood concentration of the antibodies occurred in patients running hopeless course. The authors postulated basing on their studies that the precipitins (antiproteins) would be reduced in the circulation of severe patients not only by the paralysis of production but also by increased union with corresponding antigen from active lesion.
日本結核病学会の論文

肺結核患者血中の結核菌蛋白に対する沈降抗体と補体結合抗体

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