実験的マウス結核症に対するAmikacinの効果

概要

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Amikacin (AMK) is an aminoglycoside antibiotic possessing broad antibacterial activity against Gram-positive and Gram-negative bacteria.<BR>Antibacterial activity of AMK against acidfast bacillus was compared with kanamycin (KM).<BR>In uitro study, antibacterial activity of AMK against Mycobacterium tuberculosis was similar to or stronger than KM. In uitro study on experimental tuberculosis of mice, quantitative culture of Mycobacterium tuberculosis in spleen was made, and the administration of 1 mg AMK was found to be as effective as 2 mg KM.<BR>Curative effect on pathological lesions observed in lung, liver and kidney was obtained by the administration of 1 mg of AMK, and it was almost as same as that of 2 mg KM, while the administration of 0.2 mg AMK was considerably less effective.<BR>The results obtained suggest that AMK is considerably effective as an antituberculosis agent, though the clinically full effective dose with less toxicity must be investigated in the future.
日本結核病学会の論文