Tuberactinomycin-Nに関する研究 : 第3報実験的マウス結核症に対するTUM-NおよびINHの効果

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概要

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• There have been several reports on the antituberculous activity of Tuberactinomycin-N (TUMN). The present report discusses the therapeutic effect of TUM-N on lung lesion of experimentalmouse tuberculosis.To DD strain mice weighing 20 grams, Ravenel strain of Mycobacterium bovis was intravenously inoculated and from one week after the challenge 0.1ml of 8mg/m/ INH solution and 20mg/m/ TUM-N solution was subcutaneously administered every day. Experiments were made for 5 weeks by killing 5 mice every week, respectively, for INH and TUM-N groups.<BR>The homogenized spleens were cultured on 1% Ogawas media for 8 weeks, and thereafterthe comparison was made among INH, TUM-N and the control groups by counting the bacterialcolonies. The growth of bacteria in the groups treated with INH and TUM-N was apparentlysmaller than that of the control group (Table 1).<BR>The lung lesions were histopathologically examined after macroscopic observation. The INHand TUM-N groups showed much weaker tubercle formation, exudative inflammation and caseouspneumonia than the control group (Table 2 and Photo. 1-12).<BR>The histopathological examination of the liver revealed weaker lesions in the treated groups (Table 3).<BR>The antituberculous activity of TUM-N and INH was confirmed by the quantitative culturingof the spleen and the histopathological examination of the lung, but TUM-N had weaker antituberculous activity than INH. The present experiment indicated no adverse effect of TUM-N onthe kidney.

• 日本結核病学会の論文

著者

• 成田 昭彦

  札幌医科大学第3内科

• 清水 辰典

  札幌医科大学第3内科

• 吉田 宇角

  札幌医科大学第3内科

• 奥山 富三

  札幌医科大学病理学教室

• 横山 道夫

  札幌医科大学第3内科

• 大沼 廣明

  札幌医科大学第3内科

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• 原発性肺癌に於ける気管支動脈造影の研究 : 北海道支部 : 第1回日本肺癌学会 北海道支部会
• 実験的マウス結核症に対するAmikacinの効果
• Tuberactinomycin-Nに関する研究 : 第3報実験的マウス結核症に対するTUM-NおよびINHの効果
• 重症肺結核再治療例に対するEnviornycinの治療効果

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