A Case of Lupus Vulgaris Following BCG Vaccination. II.:Characteristics of the isolated strain

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概要

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• A strain of acid-fast bacilli was isolated from a patient with "BCG-lupus". No identification of this strain could be made by morphological studies of bacilli or colonies nor by various other cultural investigations.<BR>Neither 1.0 mg of the strain nor BCG inoculated subcutaneously or intracutaneously in rabbits, guinea pigs, mice and chicken showed any affection, while the same treatment with H37Rv brought changes in the organs of all these animals except the chicken.<BR>The results of the niacin and nicotinamidase tests of this strain were similar to those of BCG, but different from those of H<SUB>37</SUB>Ra. The cord-formation of the strain was almost equal to that of BCG and Aoyama B. (A low virulent human strain used for old tuberculin in this country). Kf value of this strain was similar to that of BCG and H<SUB>37</SUB>Ra, but was lower than that of H37Rv. The strain was stained with neutral red as faintly as BCG and Aoyama B, but more feebly than H<SUB>37</SUB>Rv and H<SUB>37</SUB>Ra. The catalase activity was as strongly positive as BCG, but weaker than that of H<SUB>37</SUB>Rv and Aoyama B. The type specificity of the strain was not clearly demonstrated with the purified tuberculin as compared with that of BCG, Aoyama B or H<SUB>37</SUB>Rv.<BR>The strain was susceptible to streptomycin, paraaminosalicylic acid, isoniazid, and sulfisoxazole. In Dubos' media and Besredka's media, growth appeared with an inoculum of 10<SUP>-6</SUP> mg or more of the strain and with the same quantity of BCG, while growth of H<SUB>37</SUB>Rv and Myc. smegmatis appeared with an inoculum of 10<SUP>-8</SUP> mg. On 1%, Ogawa's egg media the growth of the strain was not distinguishable from that of H<SUB>37</SUB>Rv, Aoyama B, BCG, and Myc, smegmatis.<BR>These clinical, bacteriological, and biochemical findings led us to the assumption that the strain obtained from the lesion of the patient is BCG.

• 一般社団法人 日本結核病学会の論文

著者

• 佐藤 正弘

  東北大学抗酸菌病研究所

• 藤原 愛子

  東北大学抗酸菌病研究所

• 高橋 邦文

  東北大学抗酸菌病研究所

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• A Case of Lupus Vulgaris Following BCG Vaccination. II.:Characteristics of the isolated strain
• A Case of Lupus Vulgaris Following BCG Vaccination:I. Clinical report

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