A Case of Lupus Vulgaris Following BCG Vaccination:I. Clinical report

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In September, 1953, a healthy 4 years and 11 months old female received BCG vaccinationon the left upper arm. Three weeks latter, a dark brownish edematous swelling with papules appeared at the site of vaccination, followed by ulceration after 3 more weeks. Herfirst visit to this clinic was in April, 1955, 19months after vaccination, and the examinationsat that time revealed the following findings.Erythrocyte sedimentation rate was 16mm/hour. Tuberculin reaction (1: 2, 000 tuberculin) was positive. T. B. culture of gastric aspirateswas negative. A chest roentgenogram showedno evidence of pulmonary disease. The cutaneous lesion was confined to the left upper armand it showed scar formation accompanied withelevated ulcerations as well as lupus nodules bydiascope. Besides, scattered brownish-red papules were noticed over the upper arms, extending bilaterally to the trunk. A strain ofacid-fast bacilli was isolated from the specimensof the ulcerated parts.<BR>From these findings, lupus vulgaris followingBCG vaccination (BCG-lupus) associated withlichen scrophulosorum was suspected.<BR>As a reference, 43 cases of BCG-lupus reported up to this time were reviewed.
一般社団法人日本結核病学会の論文