肋軟骨の研究 : その2.肋軟骨の組織学的研究―その年齢的変化
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概要
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In the previous paper, histological findings of rib cartilage were studied in order to elucidate its mode of calcification and ossification on the X-ray film. In the present study, a further histological observation was made on the changes of stainability of the ground substance, atrophy and uneven distribution of the cartilage cells and the deformation of vessels in relation to age.<BR>The vessels were found in the rib cartilage of fetus and infants. This finding was contrary to the Pattens observation stating no vessel was found in the growing cartilage. Various changes appeared on the structure of “canal”(the lumina in which the vessels penetrating ground substance of the cartilage situate) in the cartilage of puberty such as fibrous, granular and cartilagelike transformation or their mixture. In the middle age or older, enlargement of the “canals” with appearance of osseous or osteoid tissue on their walls with disappearance of the vessels and the appearance of fatty and bone-marrow tissue in the lumina were noted. (Fig.1)<BR>The following changes in the stainability of the ground substance of cartilage appeared first in puberty namely, pinc halo surrounding the cartilage cells by Azan stain, black one by silver impregnating stain and dark purple ring between the halo and cartilage cells by Weigerts elastica stain (Fig.2). In the cartilage of the middle age or older, red halos by Azan stain were observed everywhere, which correlate likely with the calcium deposit in the cartilage, since the granular substances stained in blue by hematoxylin and in red by Azan were found in the rib cartilage showing evident calcification on the X-ray film. From the above findings, it is likely that the calcification of ground substance of rib cartilage begin in puberty.<BR>Fibrous transformation of ground substance of cartilage was noted slightly in infants, showed gradual increase with age, and after puberty, it was markedly found.<BR>As shown in Table, atrophy of the cartilage cells appeared in puberty, and it increased in degree with age accompanying disappearance of the nuclei. Uneven distribution of the cartilage cells was noted with atrophy of the cells in the middle age or older, and it was prominent in senile age.<BR>The columnal zone of flattened cells in the growth zone which correspond to the epiphyseal cartilage plate of long bone was thick in fetus, decreased in thickness with age and disappeared in puberty. The cystic zone of hypertrophic cells also disappeared slightly later than the disappearance of the columnal zone. (Fig.3)
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