Streptomycin依存性結核菌を用いた増殖休止菌に対する抗結核剤の効果に関する研究 : 第2編動物実験
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To evaluate the chemotherapeutic effects of antituberculosis agents against tubercle bacilli in the resting state, the author made <I>in vivo</I> experiment by using streptomycin (SM)-dependent strain of tubercle bacilli (18-b), cultivated under SM-starving condition.<BR>Mice of dd-strain, infected intravenously by 18-b, are treate d with isoniazid (INH) alone or in combination with kanamycin (KM) and ethambutol EB for eight weeks. After treatment, colonies of tubercle bacilli recovered from lung and spleen of treated mice are recorded and compared with those of untreated mice and with mice infected with tubercle bacilli in normally growing state.<BR>According to the results of this experiment, chemotherapeutic effects of antituberculosis agents such as INH, KM and EB were hardly observed against SM-dependent strain of tubercle bacilli (18-b) in the resting state under SM-starving condition of mice.
- 日本結核病学会の論文
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- Streptomycin依存性結核菌を用いた増殖休止菌に対する抗結核剤の効果に関する研究 : 第1編試験管内実験