Streptomycin依存性結核菌を用いた増殖休止菌に対する抗結核剤の効果に関する研究 : 第1編試験管内実験

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As one of the big problems of antituberculous chemotherapy for the chronic pulmonary tuberculosis, “microbial persistence”, a capacity of the drug-susceptible microorganisms which are able to survive against the activity of the drug in vivo, has been pointed out. This phenomenon indicates a limitation in tuberculosis chemotherapy other than the drug resistance. In this report, an intensified antituberculous regimen were applied in vitro upon the resting cells of streptomycin-dependent (18-b) strain, isolated from the human origin, under streptomycinstarved condition. By using silicone-coated slide culture method, kanamycin, isoniazid and ethambutol were used singly or in combination upon the resting cells. It was obtained that the drugs were slightly effective against the resting cells, but the effecte was less than that against the growing cells. This experiment suggests that tubercle bacilli in the resting state cannot survive half a year. If it is true, tubercle bacilli brought in to the resting stage might die in a relatively short period.
日本結核病学会の論文