BCG接種後のツベルクリン過敏性の推移と繰り返しツ反応の影響

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Postvaccination tuberculin reactions among infants and primary school entrants wereobserved in an area where BCG vaccination with multipuncture method had been given, practically only once in early childhood, and where postvaccination tuberculin testing had beenrepeated rather arbitrarily at varying intervals. Many of the vaccinated children were followedup in this way until the entrance of primary school. A total of 2, 085 tuberculin reactions tothe first post-vaccination test at varying intervals after vaccination showed a trend of waningof the tuberculin hypersensitivity, i. e. starting with the highest level of 16.0 mm in the meanerythema diameter with in six months after the vaccination to decrease to the minimum of 8.7mm at the sixtieth month or later. However, it was found that the school entrants who hadever been tested before showed stronger reactions than those who had never been tested, themean erythema size of the former being about 16 mm, irrespective of the numbers of intervening tuberculin tests and of the intervals between the last test and the test at the school entrancethat was at the longest three years. These findings confirm the phenomenon long known asboosting or the “restorative effect” of the postvaccination tuberculin testing to the tuberculin hypersensitivity caused by BCG vaccination. It may have serious implications on thecurrent revaccination scheme of Japan and also on the interpretation of the results of repeatedtests for mass examination as well as individual contact examination which has become anestablished routine in the tuberculosis service.
日本結核病学会の論文

BCG接種後のツベルクリン過敏性の推移と繰り返しツ反応の影響

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