BCG生菌の免疫強化作用の作用様式についての基礎的研究 (その2)
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概要
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Following the previous report, the immunopotentiating action of BCG was investigated, and results obtained were as follows:<BR>1) Combined use of BCG and cyclophosphamide (CY) which exerts a differential effect on T and B cells augmented and protracted the delayed hypersensitivity, that is to say, the T cell potentiating effect of BCG and CY were additive.<BR>2) The same additive effect was also found in the splenectomized mice without making the treatment of CY. In consequence, it could be concluded that the delayed hypersensitivity was influenced strongly by the feedback inhibition of antibody production system.<BR>3) BCG also exerted its potentiating effect for induction of the delayed hypersensitivity upon the immune response to egg albumin.<BR>4) Delayed hypersensitivity was measured as foot pad reaction. This reaction was shown to be transferred into normal recipient by draining lymph node cells and spleen cells of SRBC sensitized donor.
- 日本結核病学会の論文