BCG生菌の免疫強化作用の作用様式についての基礎的研究 (その1)

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The mice (CF1) were used for the experiment. The immunopotentiating action of BCG wasestimated by the immunologic response to the sheep red blood cells. The delayed hypersensitivitywas evaluated by the foot pad reaction and a hemagglutination test and a hemolytic plaque testwere used to assay the humoral immune response.Results obtained were as follows.<BR>1) BCG exerted its potentiating effect upon the immune response to SRBC only if BCG and SRBC were introduced into the same areas that drain to a common lymph node. The optimal intervalbetween BCG priming and the subsequent SRBC injection to produce the highest level of thedelayed hypersensitivity was about 5 to 7 weeks. The antibody formation reached its maximumabout 9 to 11 weeks when the delayed hypersensitivity was decreasing. It could reasonably beconcluded that the immunopotentiating action of BCG was biphasic following BCG injection.<BR>2) The plaque forming cells of the draining lymph node of BCG site developed in pallalelwith the resulting level of the delayed hypersensitivity. The plaque forming cells of the spleenreflected the antibody titer.
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