黒色分芽菌症の免疫化学的研究-2-3種の Hormodendrum 属糸状菌,H.pedrosoi,H.compactum およびH.dermatitidis のガラクトマンナンの血清学的性状について

概要

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Immunologically active galactomannans isolated from the mycelia and culture supernatants of 3 representative species of the genus Hormodendrum, H. pedrosoi IFO 6071, H. compactum IFO 6726, and H. dermatitidis IFO 6421, were examined for immunological cross-reactivity with the corresponding anti-whole cell rabbit sera. The following findings were obtained. 1) In both agar-gel double diffusion precipitin reaction and quantitative precipitin reaction, 6 galactomannans obtained from the three species of Hormodendrum showed strong cross-reactivity with rabbit antisera against whole cells of these species. The antigenic specificity of galactomannans from H. pedrosoi appeared to be closely related to or almost identical with that from H. compactum, while galactomannans from H. dermatitidis revealed antigenic specificity less closely related to galactomannans from any other species. The same results were obtained by the two reactions using absorbed antisera. 2) These polysaccharides were examined for specificity by passive cutaneous anaphylaxis in guinea pigs passively sensitized with unabsorbed or absorbed antisera. Reaction patterns demonstrated by the in vivo assay were consistent with those by the in vitro assay. It was suggested that these galactomannans might be major allergens of immediate type in chromoblastomycosis.
日本細菌学会の論文