担子菌チャヒラタケの産生する多糖体の抗腫瘍作用に関する研究-3-作用機序に関する二,三の検討

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It seemed likely that a mechanism similar to that of Zymosan would be involved in the antitumor action of the Crepidotus polysaccharide, since it was shown in a previous paper that both agents had several characteristics in common in their antitumor action.Although the polysaccharide exerted direct cytotoxic action in vitro at high concentraiton (500μg/ml), an additional treatment with immunosuppresser such as corticosteroid and actinomycin D resulted in complete reversion of its antitumor action. Furthermore, it was found that the treatment with the polysaccharide brought about increase in the phagocytic function of RES.These evidences were suggestive of the host-mediated action mechanism of the polysaccharide.
日本細菌学会の論文