担子菌チャヒラタケの産生する多糖体の抗腫瘍作用に関する研究-2-抗腫瘍効果について

概要

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Based on the previous finding that the Crepidotus polysaccharide exhibited a definite suppressive effect against Sarcoma 37 in mice, the effective dose, the antiumor spectrum and the route of administration were examined in this report.It was found that the injection of 250∼50mg/kg suppressed effectively the tumor in most of animals. Both pre- and post-treatment with the polysaccharide were effective. As to the route of injection, the intraperitoneal administration was most effective. The subcutaneous injection gave the least effect. When the dose was divided, 3 injections of 10μg gave high inhibition rate. While the polysaccharide suppressed the solid tumor of Ehrlich carcinoma and Sarcoma 180 in addition to Sarcoma 37, it failed to inhibit ascites form of these tumors and AH 13 ascites hepatoma in the rat. Also, a definite inhibition was not seen with syngeneic tumor such as MH 134 in C3H/He and solid tumor recently derived from spontaneous mammary carclnoma.Thus, the antitumor action of the polysaccharide showed a similar pattern to that of the yeast cell wall polysaccharide.
日本細菌学会の論文