混合ワクチンに関する研究-4-ヒトとモルモットにおけるジフテリア免疫効果の比較

概要

論文の詳細を見る
Potencies of diphtheria toxoid of combined vaccines (PD) were estimated in guinea pigs by primary response using the National Standard Diphtheria Toxoid, Plain, as a standard and were expressed in "International Unit" (I.U.). Infants aging 6 to 12 months were immunized by three injections of the vaccines with monthly intervals. Titers for diphtheria antitoxin of the serum specimens were determined a month after the last injections. The children receiving combined vaccines of 20-30 I.U. per cc had an average antitoxin titer of 1-1.3 units; while those receiving a fluid diphtheria toxoid of 3 I.U. per cc an average titer of 0.06 unit. The effectiveness of the vaccines in human beings correlated to the potency in guinea pigs, only when the number of the pertussis bacilli in a vaccine was in a certain range. The above vaccines contained 24 billion baccilli in one cc. An average antitoxin titer of the children receiving a vaccine containing 36 billion bacilli reached to 6.9 units, although the potency of the vaccine was 24 I.U., the same level as the combined vaccines described above. The discrepancy could not be explained because of the difference in the number of the injections in two animal species. The optimum number of the bacilli for the maximum adjuvant effect might vary depending on the animal species. Improvement of the assay method for combined vaccines awaits further investigations.
日本細菌学会の論文