混合ワクチンに関する研究-1-

概要

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Departmento f Bacteriologyl I, National Institute of Health, Tokyo The potency of toxoid should be assayed against to the International Standard Toxoid. Two Inter. national Standards have been already established for diphtheria toxoid, i. e. plain and adsorbed, but no standard has yet appeared for pertussis-diphtheria combined vaccine. No detailed reports have been published concerning with the dosage response curve of combined vaccine. This report is the summary of many results carried out in past several years to improve the potencytest of combined vaccine.<BR>The dosage response lines of combined vaccine were parallel with that of plain toxoid, but not of precipitated one.<BR>Addition of various amounts of tetanus toxoid to the pertussis-diphtheria vaccine did not influence. the diphtheria antitoxin production.<BR>The relative potencies of combined vaccines to the plain standard were almost similar when tested 4 to 6 weeks after immunization.<BR>From these results, it is suggested that the assay of the potency of combined vaccine shall be able. to perform against the plain standard toxoid in terms of relative potency.
日本細菌学会の論文