サルにおける赤痢菌感染実験について-3-

概要

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In these experiments, two animals of Macacus cyclopis weighing 5 kg and one animal of M. irus weighing 3, 5 kg were used. These animals were treated as follows. Before infections, sonicate of Shigella flexneri type 2 a or chloramphenicol was given into the stomach as pretreatment. Three animals were infected with 20cc (50×108/cc) living cultures of Shigella flexneri type 2a by its introduction directly into the stomach by stomach tube. The results were as follows: (1) In the pretreated monkies of 5kg weight infected with Shigella, clinical and pathological symptoms of dysentery were recognized. (2) In the pretreated monkey weighing 3, 5kg death due to Shigella infection was observed within 7 hours. Sh. flexneri was isolated from the heartblood. In the pathological observation, lesions of the lungs were seen at the anterior caudal part. Gastritis and colitis with the hemorrhage were recognized in the gastrointestinal tract.
日本細菌学会の論文