サルにおける赤痢菌感染実験について-2-

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In the previous work, the authors reported on the clinical and pathological findings in four monkies introduced with dysentery becilli into the stomach and the intestinal lumen. This report describes on the histopathological evaluations of these animals. Ml was operated upon, and bacilli were injected directly into the proximal duodenum; M 4 into the proximal caecum. They produced lesions similar to those seen in human acute small intestinal dysentery. M 2 was administered directly into the stomach. The animal revealed the lesions developed especially in the large intestine, showing acute pseudomembranous enteritis. In these animals, various degenerative changes were presented in other organs including stomach, intestinal tract, heart, lung, kidney, brain, liver and spleen. Degenerative changes in the brain were dilatation of Robin's space, degeneration of pyramidal cells, pyknosis of glianucleus, pseudoneuronphagy and karyoklasis of Purkinje's cells. In the liver, degenerative atrophia of nucleus and diffuse fatty droplets around sinusoids in the liver cells were observed. In the spleen, slight hyaline degeneration of central artery was observed.
日本細菌学会の論文