モルモット胃腸管内における赤痢菌の消長について

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The methods of administration in this experiment conformed to R. Freter's Shigella flexneri type 3a of logarithmic stage were administered directly into the stomach of guinea pigs. In the first experiment, animals were sacrificed at 1, 2, 3, 4, 6, 8, 24, 48 and 72 hours. Then, these animals were dissected and the number of dysentery bacilli in the gastrointestinal tract were examined by cultivation. 1) 113×108 live organisms were administered to each of 9 animals. These organisms passed through stomach and small intestine very quickly, and reached to the large intestine in one hour. After 72 hours, numerous dysentery bacilli were detected from the distal ileum to the distal rectum. 2) 18×106 live organisms were administered to each of 7 animals. These organisms reached to the proximal part of the large intestine in one hour. After 4 hours, dysentery bacilli were detected only in the large intestine of these animals. After 24 hours, these organisms disappeared from the gastrointestinal tract. In the second experiment, two groups of animals were used. One group was nourished witth "Sunmeal" and the other with "Oriental MF".Dysentery bacilli were administered in the animals with the techniques described above. Animals were sacrified day about. These animals were dissected and the total live dysentery bacilli in the gastrointestinal tract were counted by cultivation. 1) 5 animals on "Oriental MF" were administered 50×108 live organisms. Even after 7 days, these animals had 104-105 of total live organisms in the large intestine. 2) 4 animals on "Sun-meal" were administered 25×106 live organisms. Dysentery bacilli were detected in the large intestine up to 3 days. 3) The elevation of serum-antibody titre was observed (max.×32). But copro-antibody tests were negative.
日本細菌学会の論文

モルモット胃腸管内における赤痢菌の消長について

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