細菌のChloramphenicol不活作用に関する研究 : 第2報各種細菌のChloramphenicol不活作用と耐性との関係

概要

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A total of 588 strains. of Shigella, Escherichia, Klebsiella, Proteus, Morganella, Rettgerella, Providencia, Citrobacter, Salmonella, Pseudomonas aeruginosa, Candida albicans and Staphylococcus aureusisolated from patients in this prefecture during last two years were examined. As the result, while most of chloramphenicol resistant strains of Shigella, Klebsiella, Morganella and Staphylococcus presented the chloramphenicol inactivation activity, the sensitive strains of the bacteria and all strains of Pseudomonas andCandidawere not. The data indicate that only acquired resistant strains show the chloramphenicol inactivation. In Proteus, no correlation has been show between the resistance and the inactivation. Other species of microorganisms were all sensitive to chloramphenicol and have no inactivation activity. Furthermore, the relationship was studied on transferred resistance in vitro. The resistant strains ofShigella, Escherichia, Klebsiella, SalmonellaandCitrobactertransferred from natural resistant Escherichia and Shigella also presented the chloramphenicol inactivation. Therefore, the chloramphenicol inactivation factor seems to be closely related to the resistant factor of bacteria.
日本細菌学会の論文