ACTION SITE OF ANTAGONISTS OF VITAMIN B6 IN THE CENTRAL NERVOUS SYSTEM OF THE FROGS AND COCKROACHES

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概要

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• Susceptibility to some antagonists of vitamin B6 was studied in frogs and cockroaches after operational intervention in their central nervous systems, and also in the intact frogs and cockroaches. Thiosemicarbazide, semicarbazide, isoniazide and penicillamine induced wild jumping behavior, and tonic or clonic convulsions in frogs, when the nervous parts posterior to the optic lobe inclusive remained intact. In frog, in which the nervous parts anterior to the diencephalon inclusive had been removed, no convulsions were induced by castrix or 4-deoxy-pyridoxine in large doses. In cockroaches excessive fluttering of wings and convulsions upon administration of thiosemicarbazide following severance of the central nerve cord between the subesophageal and prothoracic ganglions were induced. Castrix was not a convulsant in the intact frogs and cockroaches.

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著者

• 山下 洵子

  Department of Anatomy and Embryology, Tokyo Metropolitan Institute for Neurosciences

• 山下 洵子

  Department of Biochemistry, Jikei University School of Medicine

関連論文

• RUNNING FITS AND γ-AMINOBUTYRIC ACID OF THE SUPERIOR COLLICULUS OF THE MOUSE
• ACTION SITE OF ANTAGONISTS OF VITAMIN B6 IN THE CENTRAL NERVOUS SYSTEM OF THE FROGS AND COCKROACHES
• CONVULSIVE SEIZURE INDUCED BY INTRACEREBRAL INJECTION OF SEMICARBAZIDE (AN ANTI-VITAMIN B6) IN THE MOUSE
• Running fit induced by injection of semicarbazide into the superior colliculus of the mouse.
• SUSCEPTIBILITY TO THIOSEMICARBAZIDE (AN ANTAGONIST OF VITAMIN B6), AND PHYLO-GENETIC AND ONTOGENETIC DEVELOP-MENT OF BRAIN
• The effect of dietary protein source on plasma cholesterol level and fecal steroid excretion in obese mice.

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