CONVULSIVE SEIZURE INDUCED BY INTRACEREBRAL INJECTION OF SEMICARBAZIDE (AN ANTI-VITAMIN B6) IN THE MOUSE

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概要

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• The direct injection of semicarbazide (SC), an antivitamin B6 (anti-B6), into the lateral ventricle of the mouse brain induced convulsion and tremors at a smaller dose after a shorter latent period than that in systemic administration. The symptoms were prevented by pyridoxine, aminooxyacetic acid or acetone, while they enhanced by pyridoxal, pyridoxal phosphate, or some other anti-B6. In mice fed a vitamin B6 (B6)-deficient diet, convulsion and tremors occurred at smaller doses of SC than those in mice given control food, and were counteracted by pyridoxine. On the other hand, mice into which SC had been injected in the neighboring site of the lambda first showed running fits, which was followed by convulsion and tremors.

• 財団法人 学会誌刊行センターの論文

著者

• 山下 洵子

  Department of Anatomy and Embryology, Tokyo Metropolitan Institute for Neurosciences

• 山下 洵子

  Department of Nutrition, Jikei University School of Medicine

関連論文

• RUNNING FITS AND γ-AMINOBUTYRIC ACID OF THE SUPERIOR COLLICULUS OF THE MOUSE
• ACTION SITE OF ANTAGONISTS OF VITAMIN B6 IN THE CENTRAL NERVOUS SYSTEM OF THE FROGS AND COCKROACHES
• CONVULSIVE SEIZURE INDUCED BY INTRACEREBRAL INJECTION OF SEMICARBAZIDE (AN ANTI-VITAMIN B6) IN THE MOUSE
• Running fit induced by injection of semicarbazide into the superior colliculus of the mouse.
• SUSCEPTIBILITY TO THIOSEMICARBAZIDE (AN ANTAGONIST OF VITAMIN B6), AND PHYLO-GENETIC AND ONTOGENETIC DEVELOP-MENT OF BRAIN
• The effect of dietary protein source on plasma cholesterol level and fecal steroid excretion in obese mice.

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