RUNNING FITS AND γ-AMINOBUTYRIC ACID OF THE SUPERIOR COLLICULUS OF THE MOUSE

スポンサーリンク

概要

• 論文の詳細を見る

• The present experiment was performed to examine the relationship between the content of γ-aminobutyric acid of the superior colliculus and running fits induced by injection of semicarbazide (SC), an antivitamin B6, into the superior colliculus of the mouse. (1) The distribution of 4-aminobutyrate: 2-oxoglutarate aminotransferase [EC 2.6.1.19] of the superior colliculus was studied histochemically. A high activity was observed in the superficial and medial gray layers of the superior colliculus. Pretreatment with aminooxyacetic acid at a dose which inhibits running fits induced by intracollicular injection of SC depressed the activity. (2) The contents of γ-aminobutyric acid in superior colliculi of mice which received an intracollicular injection of SC were 60 per cent of the control, when measured immediately after the first running fit. Administration of pyridoxine together with SC inhibited the fall. (3) Intracollicular injection of thiosemicarbazide and 4-deoxypyridoxine, other antivitamins B6, also induced running fits. These results suggest that the running fits by SC injected intracollicularly are induced by the decrease of γ-aminobutyrate due to insufficient vitamin B6 in the superior colliculus.

• 財団法人 学会誌刊行センターの論文

著者

• 山下 洵子

  Department of Anatomy and Embryology, Tokyo Metropolitan Institute for Neurosciences

• 平田 幸男

  Department of Anatomy and Embryology, Tokyo Metropolitan Institute for Neurosciences

関連論文

• RUNNING FITS AND γ-AMINOBUTYRIC ACID OF THE SUPERIOR COLLICULUS OF THE MOUSE
• ACTION SITE OF ANTAGONISTS OF VITAMIN B6 IN THE CENTRAL NERVOUS SYSTEM OF THE FROGS AND COCKROACHES
• CONVULSIVE SEIZURE INDUCED BY INTRACEREBRAL INJECTION OF SEMICARBAZIDE (AN ANTI-VITAMIN B6) IN THE MOUSE
• Running fit induced by injection of semicarbazide into the superior colliculus of the mouse.
• SUSCEPTIBILITY TO THIOSEMICARBAZIDE (AN ANTAGONIST OF VITAMIN B6), AND PHYLO-GENETIC AND ONTOGENETIC DEVELOP-MENT OF BRAIN
• The effect of dietary protein source on plasma cholesterol level and fecal steroid excretion in obese mice.

スポンサーリンク