MECHANISM OF INACTIVATION OF BACTERIOPHAGE MS2 CONTAINING SINGLE-STRANDED RNA BY ASCORBIC ACID

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概要

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• The mechanism of inactivation of a single-stranded RNA phage, MS2, by AsA was investigated as a part of the studies on the mechanism of inactivation of viruses by AsA. Investigations on the effects of oxygen, oxidizing or reducing agents, metals or chelating agents, and free radical scavengers on the inactivation of the RNA phage by AsA indicated that the free radical intermediates formed during the course of oxidation of AsA are responsible for the inacti vation of the phage. Hydrogen peroxide and DAsA themselves had no effect on the infectivity of the phage. Sucrose density gradient centrifugation analyses indicated that the reactive radicals react with the phage RNA to cause strand scissions in the RNA.

• 財団法人 学会誌刊行センターの論文

著者

• 村田 晃

  Laboratory of Applied Microbiology, Department of Agricultural Chemistry, Saga University

• 鵜池 素子

  Laboratory of Applied Microbiology, Department of Agricultural Chemistry, Saga University

• 村田 晃

  Laboratory of Applied Microbiology, Department of Agricultural Chemistry, Saga Univeristy

関連論文

• MECHANISM OF INACTIVATION OF BACTERIOPHAGE MS2 CONTAINING SINGLE-STRANDED RNA BY ASCORBIC ACID
• Virus-inactivating effect of ascorbic acid. IV. Mechanism of inactivation of bacteriophage .DELTA..DELTA. containing single-stranded DNA by ascorbic acid.
• Effect of vitamins other than vitamin C on viruses: Virus-inactivating activity of vitamin K5.
• Virus-inactivating effect of D-isoascorbic acid.

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