Virus-inactivating effect of D-isoascorbic acid.

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概要

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• The effect of D-isoascorbic acid, an epimer of L-ascorbic acid, on viruses was investigated using a wide variety of bacterial viruses (phages) as model systems. D-Isoascorbic acid exerted an inactivating effect on all phages examined. The reaction mechanism of virus inactiva-tion by D-isoascorbic acid was investigated using phage J 1 as a model system. Bubbling oxygen through the reaction mixture and the addition of H2O2 or transition metal ions into the reaction mixture enhanced the phage inactivation by D-isoascorbic acid. In contrast, nitrogen bubbling and the addition of reducing agents, chelating agents or radical scavengers prevented phage inactivation. Experiments using specific radical scaven-gers, superoxide dismutase or catalase showed that OH⋅ could be mainly responsible for phage inactivation by D-isoascorbic acid. These findings are similar to those obtained with L-ascorbic acid, and indicate that phage-inactivating activity is independent of the stereoisomerism with inversion of the hydroxyl group at carbon 5 of ascorbic acids.

• 財団法人 学会誌刊行センターの論文

著者

• 村田 晃

  Laboratory of Applied Microbiology, Department of Agricultural Chemistry, Saga Univeristy

• 加藤 富民雄

  Laboratory of Applied Microbiology, Department of Agricultural Chemistry, Saga University

• 川崎 雅彦

  Laboratory of Applied Microbiology, Department of Agricultural Chemistry, Saga University

• 本松 宏子

  Laboratory of Applied Microbiology, Department of Agricultural Chemistry, Saga University

関連論文

• MECHANISM OF INACTIVATION OF BACTERIOPHAGE MS2 CONTAINING SINGLE-STRANDED RNA BY ASCORBIC ACID
• Virus-inactivating effect of ascorbic acid. IV. Mechanism of inactivation of bacteriophage .DELTA..DELTA. containing single-stranded DNA by ascorbic acid.
• Effect of vitamins other than vitamin C on viruses: Virus-inactivating activity of vitamin K5.
• Virus-inactivating effect of D-isoascorbic acid.

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