Effect of .ALPHA.-tocopherol on the binding of benzo(a)pyrene to nuclear macromolecules.

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概要

• 論文の詳細を見る

• The binding of metabolically activated 14C-benzo(a)pyrene (BP) to rat liver nuclei was studied. The nuclear framework structure, termed the nuclear matrix, was found to bind BP preferably. α-Tocopherol inhibited the binding of BP to nuclear macromolecules in the presence of phenobarbital (PB)-induced microsomes. α-Tocopherol decreased the level of BP metabolites in nuclei, though it did not inhibit the activation of BP by PB-induced microsomes.

• 財団法人 学会誌刊行センターの論文

著者

• 上山 久雄

  Department o f Medical Biochemistry, Shiga University of Medical Science

• 上田 潔

  Department o f Medical Biochemistry, Shiga University of Medical Science

• 能見 伸八郎

  Department o f Medical Biochemistry, Shiga University of Medical Science

• 松浦 尚雄

  Department o f Medical Biochemistry, Shiga University of Medical Science

関連論文

• Effect of Vitamin A Compounds on the Covalent Binding of Benzo (a) pyrene to Nuclear Macromolecules
• Occurrence of NADH-Diaphorases in Isolated Thymus Nuclei
• Effect of .ALPHA.-tocopherol on the binding of benzo(a)pyrene to nuclear macromolecules.
• Detection of reaction products of thiamin degradation by catechol derivatives.
• Isolation and characterization of a coupled compound of thiamin with catechol.

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