The effects of orally administered linoleic acid and its autoxidation products on intestinal mucosa in rat.

スポンサーリンク

概要

• 論文の詳細を見る

• Linoleic acid and its autoxidation products, hydroperoxides and their secondary products, were orally administered to rats (350mg each/rat). Hemorrhage was seen in the alimentary canal at 6 h after the dose of hydroperoxides. To examine their toxicities on intestinal mucoua, the activities of mucous enzymes (sucrase, maltase, and alkaline phosphatase) were measured. Hydroperoxides and their secondary products decreased the enzyme activities in jejunum at 6 h after the doses and increased them in both jejunum and ileum at 15 h, as compared to linoleic acid or saline solution. The decrease of enzyme activity was marked in the hydroperoxide group and the increase was marked in the secondary product group. Then, in in vitro experiments, the effects of autoxidation products on these enzymes were determined. Autoxidation products inactivated only alkaline phosphatase. Thus, the results in vivo disagreed with those in vitro. It was assumed that autoxidation products orally administered attacked a membrane of intestinal microvilli whereas in vitro they directly affected the enzymes.

• 財団法人 学会誌刊行センターの論文

著者

• 団野 源一

  Department of Agricultural Chemistry, Faculty of Agriculture, Kobe University

• 名武 昌人

  Department of Agricultural Chemistry, Faculty of Agriculture, Kobe University

• 芦田 均

  Division of Utilization of Biological Resources, Kobe University

• 金沢 和樹

  Department of Agricultural Chemistry

• 源 伸介

  Division of Utilization of Biological Resources, Kobe University

• 団野 源一

  Department of Agricultural Chemistry

• 名武 昌人

  Department of Agricultural Chemistry

関連論文

• LYSOZYME DAMAGE CAUSED BY SECONDARY DEGRADATION PRODUCTS DURING THE AUT-OXIDATION PROCESS OF LINOLEIC ACID
• Depletion of Hepatic Coenzyme A Derivatives Is One of the Markers of the Toxicity of Orally Administered Secondary Autoxidation Products of Linoleic Acid in Rat
• Formation of DNA-damaging and mutagenic activity in the reaction systems containing nitrite and butylated hydroxyanisole, tryptophan, or cysteine.
• Succinate Dehydrogenase and Synthetic Pathways of Glucose 6-Phosphate Are also the Markers of the Toxicity of Orally Administered Secondary Autoxidation Products of Linoleic Acid in Rat Liver
• The effects of orally administered linoleic acid and its autoxidation products on intestinal mucosa in rat.
• Effects of dose levels of autoxidized linoleic acid on the drug-metabolizing system in rat liver.
• Effect of autoxidized linoleic acid on the contents of cytochrome P-450 and cytochrome b5, and drug-metabolizing enzyme activities in rat liver.

スポンサーリンク