Effects of dose levels of autoxidized linoleic acid on the drug-metabolizing system in rat liver.

スポンサーリンク

概要

• 論文の詳細を見る

• Autoxidized linoleic acid (AL) having 800meq/kg of per-oxide value and 1, 700 meq/kg of carbonyl value was given in repeated oral doses at a daily dose of 0 (control)-7.5ml/kg to male Wistar rats for 5 successive days. The effect of increasing AL dose on the drug-metabolizing system was investigated in rat liver microsomes and S-9 fractions. All the rats of a daily dose of 5.0-7.5ml/kg died after the third day of consecutive oral doses. The cytochrome P-450 and b5 contents, enzyme activities in electron transfer system, aminopyrin-N-demethylase activity and S-9 activity (metabolic activation of 2-acetylaminofluorene) in the drug-metabolizing system changed essentially in a similar manner, that is, both the contents and the activities were increased by a small dose of AL, and were decreased by a large dose of AL. These results strongly supported the findings in a previous report wherein we observed the periodical effect of AL dose on the drug-metabolizing system.

• 財団法人 学会誌刊行センターの論文

著者

• 名武 昌人

  Department of Agricultural Chemistry

• 岸田 忠昭

  Himeji Women's College

• 岸田 忠昭

  Himeji College of Hyogo, Shinzaikehoncho

• 平松 直子

  Himeji Women's College

関連論文

• LYSOZYME DAMAGE CAUSED BY SECONDARY DEGRADATION PRODUCTS DURING THE AUT-OXIDATION PROCESS OF LINOLEIC ACID
• Formation of DNA-damaging and mutagenic activity in the reaction systems containing nitrite and butylated hydroxyanisole, tryptophan, or cysteine.
• Succinate Dehydrogenase and Synthetic Pathways of Glucose 6-Phosphate Are also the Markers of the Toxicity of Orally Administered Secondary Autoxidation Products of Linoleic Acid in Rat Liver
• The effects of orally administered linoleic acid and its autoxidation products on intestinal mucosa in rat.
• Effects of dose levels of autoxidized linoleic acid on the drug-metabolizing system in rat liver.
• Effect of autoxidized linoleic acid on the contents of cytochrome P-450 and cytochrome b5, and drug-metabolizing enzyme activities in rat liver.

スポンサーリンク