α-Tocopherol Protects the Peroxidative Modification of LDL to Be Recognized by LDL Receptors
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概要
- 論文の詳細を見る
Background: Peroxidatively modified low-density lipopro-tein (LDL) may contribute to the atherosclerotic process; therefore, pro-tecting LDL against peroxidation may reduce or retard the progression of atherosclerosis. We evaluated the effect of α-tocopherol on copper-catalyzed LDL peroxidative modification. Methods: The protective effects of a-tocopherol on copper-catalyzed LDL peroxidative modification were examined by measurement of the concentration of lipid hydroperoxides in LDL and by the provision of LDL cholesterol to lymphocytes via the LDL receptor-mediated pathway. Results: The measurement of concentration of lipid hydroperoxides in LDL showed that a-tocopherol inhibited the peroxidative modification of LDL. Also, α-tocopherol preserved the ability of LDL to be recognized by LDL receptors in peripheral blood lymphocytes to the same extent as native LDL. Conclusion: These findings indicate that α-tocopherol may protect LDL against peroxidative modification, maintaining its ability to act as a ligand for LDL receptors in vivo.
- 財団法人 学会誌刊行センターの論文
著者
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Hibino T
Department Of Internal Medicine And Pathophysiology Nagoya City University Graduate School Of Medica
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Yoshikawa Masae
Third Department Of Internal Medicine Nagoya City University Medical School
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FUJINAMI Takao
The Third Departmenr of Internal Medicine,Nagoya City University Medical School
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SAKUMA Nagahiko
The Third Department of Internal Medicine
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HIBINO Takeshi
The Third Department of Internal Medicine
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TAMAI Nozomu
The Third Department of Internal Medicine
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KUNIMATSU Mitoshi
The Second Department of Biocemistry, Nagoya City University Mediccal School
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Sakuma N
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Yoshikawa Masaki
Third Department Of Internal Medicine Nagoya City University Medical School
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YOSIKAWA Masae
The Third Department of Internal Medicine Nagoya City University, Medical School
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OKADA Masaml
The Third Department of Internal Medicine Nagoya City University, Medical School
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JINNO Yasunari
The Third Department of Internal Medicine Nagoya City University, Medical School
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SASAI Kanna
The Third Department of Internal Medicine Nagoya City University, Medical School
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YOSHIMATA Takayuki
The Third Department of Internal Medicine Nagoya City University, Medical School
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HIBINO Takeshi
The Third Department of Internal Medicine Nagoya City University, Medical School
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SAKUMA Nagahiko
The Third Department of Internal Medicine Nagoya City University, Medical School
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FUJINAMI Takao
The Third Department of Internal Medicine Nagoya City University, Medical School
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KUNIMATSU Mitoshi
The Second Department of Biochemistry, Nagoya City University, Medical School
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TAMAI Nozomu
The Third Department of Internal Medicine Nagoya City University, Medical School
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