Vitamin E Is an Important Factor in T Cell Differentiation in Thymus of F344 Rats.
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概要
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The effect of vitamin E (dl-a-tocopheryl acetate) on T cell differentiation in thymus of F344 rats was examined in this study. The rats were divided into three groups: vitamin E-free, regular and high vitamin E groups and fed a diet containing various levels of vitamin E (0, 50, and 585 mg/kg diet) for 7 weeks. The number of thymocytes was significantly lower in the vitamin E-free group relative to the regular group. Although the proportions of both CD4 CD8- and CD4-CD8+ T cells in thymocytes were significantly greater in the high vitamin E group, the proportion of CD4+CD8- T cells inversely decreased in vitamin E-free group compared to that of the regular group. The ratio of CD4+ CD8-/CD4-CD8 T cells increased in the high vitamin E group (p<0.01) and significantly decreased in the vitamin E-free group (p<0.001) compared to that of the regular group. Although the marked changes of T cell subsets were not seen in peripheral blood lymphocytes (PBL), the ratio of CD4+CD8-/CD4-CD8 T cells was significantly lower in the vitamin E-free group and significantly greater in the high vitamin E group compared to that of the regular group. Production of interleukin (IL) 2 by thymocytes following the stimulation with Con A for 48 h increased about threefold in the high vitamin E group compared to the regular group. Conversely, thymocytes from rats fed the vitamin E-free diet showed a significant decrease of IL2 production compared to that of the regular group. Prostaglandin E2 (PGE2) production from thymocytes was significantly lower in the high vitamin E group compared to that of the regular group, whereas thymocytes of rats fed the vitamin E-free diet showed a significant increase of PGE2 production compared to that of rats fed the regular diet. Furthermore, in vitro addition of indomethacin provided a restoration of IL2 production from thymocytes of rats fed the vitamin E-free diet to the level of rats fed the regular diet. These results suggest that vitamin E plays an important role in T cell differentiation in thymus, which may be related to the action of vitamin E as antioxidant.
- 財団法人 学会誌刊行センターの論文
著者
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MAEDA Kenichi
Department of Small Animal Surgery 1, School of Veterinary Medicine, Kitasato University
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Kishino Yasuo
Department Of Nutrition School Of Medicine The University Of Tokushima
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Moriguchi Satoru
Department Of Human Nutrition Faculty Of Nursing And Human Nutrition Yamaguchi Prefectural Universit
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Okamura Mariko
Department Of Chemistry Faculty Of Science Kochi University
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MIWA Hitomi
Department of Nutrition
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MAEKAWA Keisei
Department of Nutrition
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KISHINO Yasuo
Department of Nutrition
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