Utilization and Metabolism of (U-14C)4' Galactosyllactose (O-.BETA.-D-Galactopyranosyl-(1.RAR.4)-O-.BETA.-D-Galactopyranosyl-(1.RAR.4)-D-Glucopyranose) in Rats.

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0-β-D-Galactopyranosyl-(1→4)-O-β-D-galactopyranosyl(1→4)-D-glucopyranose (designated as 4'GL) are produced from lactose with Cryptococcus laurentii OKN-4. Excretion and metabolism of 4'GL in rats were examined using a radioisotope technique. [U-14C]4'GL was synthesized from [U-14C]lactose by Cryptococcus laurentii OKN-4. The 14`02 in expired air was counted after oral administration of [U-14C]4'GL or [U-14C]lactose in conventional rats, rats treated with antibiotics and germ-free rats. The rate of 14CO2 excretion from conventional rats given [U-14C]4'GL was slower than that from those administered [U-14C]lactose. When [U-14C]4'GL was orally administered to rats given antibiotics, there was a 2-h delay in 14C02 excretion, as compared to conventional rats. In germ-free rats, total excretion of 14C02 from [U-14C]4'GL decreased to about one-third of that of conventional rats during a 24-h period. Radioactivities in the serum, liver, and carcass of the [U-14C]4'GL oral administration group were lower than those of the [U-14C]lactose oral administration group. Radioactivities in the feces and urine however, were higher in [U-14C]4'GL group than in [U-14C] lactose group.
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