Effect of a histidine-excess diet on a tetrahydrofolylpolyglutamate pattern in rat liver.

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概要

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• The effect of a histidine-excess diet on the hepatic folylpol-yglutamate pattern in rat was studied. Rats were fed ad libitum 9.7% casein basal diets with 0.6% methionine (controls) or the basal diets with 3.5% histidine. The average daily weight gain and the food intake in histidine-supplemented rats (His-rats) did not significantly differ from controls. The liver weight in His-rats, however, was 50% higher than controls. Hepatic methyltetrahydropteroylpentaglutamate (CH3-H4PteGlu5), and tetrahydropteroylmonoglutamate concentrations in His-rats was 5.7- and 2-fold higher than controls, respectively. The tetrahyd-ropteroylpentaglutamate (H4PteGlu5) concentration in the His-rats was 74% lower than controls. Considering the homeostasis of folate cofactors in tissues, these results suggest that the hepatic regeneration systems for H4PteGlu5 in His-rats might be repressed and an apparent methylfolate trap might be attained rather on a pteroylpentaglutamate level than a monoglutamate level, and that the activity for catabolizing the excess histidine might exceed the regenerating activity for folate cofactors.

• 財団法人 学会誌刊行センターの論文

著者

• 岩井 和夫

  Laboratory of Nutritional Chemistry, Department of Food Science and Technology, Faculty of Agriculture, Kyoto University

• 小橋 昌裕

  Laboratory of Nutritional Chemistry, Department of Food Science and Technology, Faculty of Agriculture, Kyoto University

• 高橋 麻子

  Laboratory of Nutritional Chemistry, Department of Food Science and Technology, Faculty of Agriculture, Kyoto University

関連論文

• Increase in growth rate and activity of the tryptophan-NAD pathway caused by di-n-butylphthalate in rats fed on a tryptophan-limited diet.
• Metabolic control for maintaining NAD in rats fed on tryptophan-limiting amino acid diets.
• Effect of tryptophan and/or casein supplementation on NAD levels in livers of the rats fed on niacin- and protein-free diet.
• Effect of a histidine-excess diet on a tetrahydrofolylpolyglutamate pattern in rat liver.

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