Comparisons of urinary creatinine, skeletal muscle mass, and indices of muscle protein catabolism in rats fed ad libitum, with restricted food intake, and deprived of food.
スポンサーリンク
概要
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Urinary excretions of creatinine (CR) and 3-methylhistidine (3-MeHis), and skeletal muscle mass (SKM) were measured in rats (male, Wistar, weighing about 290g) fed a 20% casein diet ad libitum, rats restricted to 70% of the food intake of the ad libitum group, and rats deprived of food for 20 days. At the same time, catabolic rates of muscle protein derived from 3-MeHis/CR, 3-MeHis/BW, and 3-MeHis/SKM were compared. The CR/SKM ratio in the energy-restricted group was similar to the ad libitum group, while the ratio was higher in the food-deprived group than in the other two groups. This means that CR excretion was promoted per unit of skeletal muscle mass by food deprivation. These results indicate that CR excretion can be an index for SKM under the condition of energy restriction, but not under the condition of food deprivation. The present data also suggest that it is possible to use the 3-MeHis/CR ratio instead of 3-MeHis/SKM which is the most reliable index of the three indices, under the condition of mild energy restriction. In food deprivation, however, the 3-MeHis/CR data tended to underestimate the catabolic rate of muscle protein compared with the 3-MeHis/SKM data. The 3-MeHis/BW data was similar to the 3-MeHis/SKM with all dietary conditions. The catabolic rate of muscle protein was constant or decreased very slightly under ad libitum feeding, decreased slightly in energy restriction, and increased drastically with food deprivation.
- 財団法人 学会誌刊行センターの論文
著者
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藤田 美明
Nutrition Research Laboratory, TOkyo Metropolitan Institute of Gerontology
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力丸 徹
Nutrition Research Laboratory, TOkyo Metropolitan Institute of Gerontology
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大関 知子
Nutrition Research Laboratory, Tokyo Metropolitan Institute of Gerontology
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海老沢 秀道
Nutrition Research Laboratory, Tokyo Metropolitan Institute of Gerontology
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市川 みね子
Nutrition Research Laboratory, Tokyo Metropolitan Institute of Gerontology
関連論文
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- Effect of Quality and Quantity of Dietary Protein on Free Amino Acids in Plasma and Tissues of Adult Rats
- UTILIZATION OF N-ACETYL-L-TRYPTOPHAN GIVEN INTRAVENOUSLY TO UNRESTRAINED ADULT RATS
- Comparisons of urinary creatinine, skeletal muscle mass, and indices of muscle protein catabolism in rats fed ad libitum, with restricted food intake, and deprived of food.
- Effects of low protein intake on protein metabolism of Papua New Guinea highlanders studied with (15N)glycine.
- Blood status and serum free amino acids in Papua New Guinea highlanders.
- Long-term effect of energy restriction at different protein levels on several parameters of nutritional assessment.
- Utilization of urea nitrogen in Papua New Guinea highlanders.
- Age-related changes in nitrogen balance and related variables in later life of aging male Wistar rats.