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L-CEX (long acting Cephalexin) has, a, blood effective hour about twice longer than that of CEX, so that the recommended dose of L-CEX is 500mg b. i. d as compared to 250mg, q. i. d or 500mg, t. i. d with CEX.<BR>In the present study, the blood concentration of cephalexin was examined with time lapse for determining its optimum dose and frequency of administration. A cross over test of L-CEX and CEX was performed in 4 healthy male adults. Four groups were examined; Group I L-CEX 500mg, twice a day; Group II L- CEX 500mg, three times a day; Group III CEX 250mg, four times a day; and Group IV CEX 500mg, three times a day. The blood concentration was monitored on and after the first administration for 24 hours. The determination of blood levels was performed on serum samples by a cylinder method.<BR>With the same dose given, L- CEX showed a lower peak serum concentration but more prolonged effective hour as compared to CEX. The serum effective hour was 11.2 hours in Group I, 18.7 hours in Group II, 10.6 hours is Group III and 13.4 hours in Group IV.<BR>The usefulness of L-CEX was confirmed from the fact that the bactericidal effect of cephalexin shows a time-dependency. Furthermore, a dose regimen for L-CEX of 500mg, three times a day, is considered to be of most effective administration.
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