Rise and fall of serum concentration of long acting amoxicillin in continuos administration.

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In order to prolong the serum consentration, long ating Amoxicillin (L-AMPC) prescribed the mixtures of 30% of non-coated granules and 70% of enteric-coated granules dissolvable on and above pH 6. In the present study, the serum concentration of L-AMPC and AMPC was examined using a time lapse for determining its optimum dose and frequency of administration.A cross over test for L-AMPC and AMPC was performed in 4 healthy male adults.Four groups were examined;Group I L-AMPC 500 mg, twice a day;Group II L-AMPC 500 mg, three times a day;Group III AMPC 250 mg, three times a day;Group IV AMPC 250 mg, four times a day.The serum concentration was monitered on and after the first administration for 24 hours.The determination of serum levels was performed on serum samples by a cylinder method. The serum effective hour (MIC: 1.56μg/ml) was 15.0 hours in Group I, 19.9 hours in Group II, 10.7 hours in Group III, 11.7 hours in Group IV. The serum AUC (MIC: 1.56μg/ml) was 15.724μg·hr/ml in Group I, 20.580μg·hr/ml in Group II, 7.856μg·hr/ml/ml in Group III, 11.793μg·hr/ml in Group IV.
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