A histopathological study of the condylar cartilage in experimental osteolathyrism. Degenerative changes and repair of the chondrocyte.:Degenerative changes and repair of the chondrocyte

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概要

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• The experiment reported in this paper was designed to clarify degenerative changes and repair of the proliferation and differentiation of the condylar chondrocytes by causing osteolathyrism experimentally.<BR>Experimental methods: Growing 4-week-old male Wistar rats were experimental animals.<BR>In order to produce the experimental osteolathyrism, 2% aminoacetonitrile (AAN) in physiological saline solution was injected in rats at a dose level of 20mg/100g body weight, intraperitoneally. The AAN administration was performed four with methods; only 1time, 2 times, 4 times and 7 times a week. From these administered methods, the experimental rats were divided into three groups: control, AAN administered and 1 week after AAN administration.<BR>After the end of treatment, all experimental rats in each group were sacrificed and examined for histopathological findings.<BR>Experimental results: The 4-week-old rats in the control group had active growth, active proliferation and differentiation of the mandibular cartilage-cells. On the other hand, the characteristic changes of osteolathyrism were observed in the AAN administered group.<BR>The AAN administered rats of 4 times and 7 times a week showed loss of appetite and depression of gained body weight, etc. in general condition. In the condylar cartilage, a decrease in the fibroblasts, a decrease in chondrocytes and disordered differentiation of the chondrocytes were observed. In addition, AAN administered rats of 7 times a week showed a disturbance of the endochondral bone formation.<BR>In the "1-week after AAN administration" group, repair of the condylar cartilage, which had active proliferation of the fibroblasts and normally differentiation of the chondrocytes were observed.

• 社団法人 日本口腔外科学会の論文

著者

• 大平 三四郎

  金沢医科大学歯科口腔外科学教室

• 船本 長一朗

  金沢医科大学口腔外科学教室

• 吉田 徹

  金沢医科大学歯科口腔外科学教室

• 高沢 一良

  金沢医科大学歯科口腔外科学教室

• 中村 哲

  金沢医科大学歯科口腔外科学教室

• 塩田 覚

  金沢医科大学医学部歯科口腔外科学教室

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